Viral Pathogenesis
Activity
RESEARCH TOPICS
The Laboratory of Viral Pathogenesis has gained a considerable amount of expertise in the study of the Interferon-inducible protein IFI16 and the mechanisms it relies on to regulate various cell functions, including autoimmunity and viral replication control, with a main focus on Human Cytomegalovirus (HCMV) and Papillomavirus (HPV). Moreover, other projects of the lab are dedicated to investigate existing correlations between the HCMV genetic make-up, including virus- and cell-derived genes, and miRNA expression profile, and the activation of the host innate immune response leading to organ failure. Finally, a research topic of the lab is dedicated to the study of HPV role in the carcinogenesis.
CURRENTPROJECTS
PRIN 2012 (Santo Landolfo):
Novel pathogenetic mechanisms elicited by herpesviruses in degenerative diseases and cancer
PRIN 2012 (Valentina Dell’Oste): High-throughput analysis of beta-Papillomaviruses infection/reactivation in the immunocompromised host for understanding virus-host interactions and their pathogenic role in developing malignancies
"ESCMID Research Grant 2013 "A multidisciplinary approach to dissect the role of viral infections in the pathogenesis of systemic autoimmune diseases";
Ricerca finanziata dall'Università (ex-60%) 2012 "La proteina Interferon-inducibile IFI16: fattore di restrizione per la replicazione degli Herpesvirus umani";
Ricerca finanziata dall'Università (ex-60%) 2012 "I geni interferon-inducibili HIN200 come marcatori diagnostici e prognostici delle malattie autoimmuni sistemiche";
Ricerca finanziata dall'Università (ex-60%) 2012 "Studio del ruolo dei beta-papillomavirus umani (beta-HPV) nella cancerogenesi cutanea in associazione con i raggi ultravioletti";
FIRB-Programma "Futuro in ricerca" 2008 "Utilizzo di modelli umani e murini per la comprensione dei meccanismi patogenetici coinvolti nella carcinogenesi cutanea indotta da Papillomavirus umani".
Publications
Research Products of Santo Landolfo
Research Products of De Andrea Marco
Research Products of Dell'Oste Valentina
Research Products of Gugliesi Francesca
Research Products of Biolatti Matteo
Research Products of Giorgio Alessandro
Research Products of Lo Cigno Irene
Tag: HCMV, HPV, INTERFERON, IFI16