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PICTURE
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Bacteriology and Mycology

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Activity

RESEARCH LINES

Bacteriology and Mycology Laboratory focuses its activities on the interactions between antimicrobial agents (antibiotics, antifungal agents, essential oils, natural compounds) and aspecific immunity in bacterial and fungal infections. This research line includes: the evaluation of the in vitro activity of antimicrobial agent towards bacteria, yeasts and filamentous fungi; the investigation of drug immunomodulatory activity on primary functions of phagocytes (phagocytosis, intracellular microbicidal activity and cytokine release) in healthy and immunocompromised subjects against clinical pathogens (Gram-positive and Gram-negative bacteria, mycetes).

In addition, the following clinical researches are conducted:
-   studies on the functional and phenotypical alteration of polymorphonuclear cells from patients with lymphoproliferative disorders and skin diseases (Sézary syndrome, atopic dermatitis, mycoses fungoides);
-   studies on the functional activity of phagocytes from multiple sclerosis patients at different disease stages (RR – CP) treated with immunomodulating and immunosuppressive drugs;
-   studies on oxygen nanobubbles (ONBs) loaded with antimicrobial agents  as antibacterial vectors for  treatment of cutaneous bacterial infections in diabetic patients;
-   studies on gut microbiota composition of pediatric subjects;
-   studies on the incidence of dermatophytes and related fungi in humans and animals;
-   studies on the microbial adhesion to different biomaterials used in orthopaedic surgery related to their specific physico-chemical properties;
-   studies on the incidence and risk factors for microbial infection after proximal humeral fractures;
-   studies on the microbiological evaluation of diagnostic and therapeutic tools in oral surgery.

 

CURRENT PROJECTS

2012

-   ESCMID Research Grant 2012 – “Phagocytes in multiple sclerosis: altered microbicidal functions related to the disease.”

-   Research funded by the University (ex-60%)  – “Immunological profile of patients with infection-related immune deficiency: study of phagocyte microbicidal activity and potential therapeutic approaches.”

-   Research funded by the University (ex-60%) – “Interaction between innate immunity and antimicrobial agents in pediatric microbial infections.”

 

2013

-   Research funded by the University (ex-60%) – “Phagocytes in multiple sclerosis: impairment of their functions related to the disease.”

-   Research funded by the University (ex-60%) – “Antifungal activity of essential oils and their influence on the innate immune system in eradicating intracellular yeasts.”

-   Research funded by the University (ex-60%) – “Microbial adhesion to different biomaterials used in orthopaedic surgery related to their specific physico-chemical properties.”

-   Research funded by the University (ex-60%) – “Modulation of ciprofloxacin in the PMN response towards different antibiotic-resistant and susceptible species of Lactobacillus.”

-   Research funded by the University (ex-60%) – “Evaluation of the functional alteration of polymorphonuclear cells in primary cutaneous T-cell lymphoma (mycosis fungoides).”

Tag: ANTI MICROBIC AGENTS, ASPECIFIC IMMUNITY, PATHOGENS (BACTERIA, YEASTS AND FILAMENTOUS FUNGI)

Last update: 06/10/2015 14:28
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