The Laboratory of Viral Pathogenesis has gained a considerable amount of expertise in the study of the Interferon-inducible protein IFI16 and the mechanisms it relies on to regulate various cell functions, including autoimmunity and viral replication control, with a main focus on Human Cytomegalovirus (HCMV) and Papillomavirus (HPV). Moreover, other projects of the lab are dedicated to investigate existing correlations between the HCMV genetic make-up, including virus- and cell-derived genes, and miRNA expression profile, and the activation of the host innate immune response leading to organ failure. Finally, a research topic of the lab is dedicated to the study of HPV role in the carcinogenesis.
PRIN 2012 (Santo Landolfo):
Novel pathogenetic mechanisms elicited by herpesviruses in degenerative diseases and cancer
PRIN 2012 (Valentina Dell’Oste): High-throughput analysis of beta-Papillomaviruses infection/reactivation in the immunocompromised host for understanding virus-host interactions and their pathogenic role in developing malignancies
"ESCMID Research Grant 2013 "A multidisciplinary approach to dissect the role of viral infections in the pathogenesis of systemic autoimmune diseases";
Ricerca finanziata dall'Università (ex-60%) 2012 "La proteina Interferon-inducibile IFI16: fattore di restrizione per la replicazione degli Herpesvirus umani";
Ricerca finanziata dall'Università (ex-60%) 2012 "I geni interferon-inducibili HIN200 come marcatori diagnostici e prognostici delle malattie autoimmuni sistemiche";
Ricerca finanziata dall'Università (ex-60%) 2012 "Studio del ruolo dei beta-papillomavirus umani (beta-HPV) nella cancerogenesi cutanea in associazione con i raggi ultravioletti";
FIRB-Programma "Futuro in ricerca" 2008 "Utilizzo di modelli umani e murini per la comprensione dei meccanismi patogenetici coinvolti nella carcinogenesi cutanea indotta da Papillomavirus umani".
Tag: HCMV, HPV, INTERFERON, IFI16