Study of the exposure and effects of environmental and occupational particulate pollutants
Principal Investigator (PI)/Coordinator: Prof. Enrico Bergamaschi
- Prof. Enrico Bergamaschi, Full Professor, Head of research team
- Dr. Giacomo Garzaro, Senior lecturer
- Dr. Davide Bosio, Medical Executive (National Health Service)
- Dr. Maria Grazia Putzu, Medical Executive (National Health Service)
- Prof. Ivana Fenoglio, Associate Professor (Department of Chemistry)
- Prof. Chiara Riganti, Full Professor (Department of Oncology)
- Prof. Paola Cassoni, Full Professor (Department of Medical Sciences)
- Dr. Giuseppe Mariella, Technician
Toxicology of nanostructured materials and biomaterials and assessment of the exposure and effects of nanomaterials and micro and nano-plastics in the work and living environment and on health:
- Study of the interactions of natural and artificial nanomaterials (NM) with the biological systems using advanced in vitro models (3D cultures, organoids, microfluidics), structural determinants of toxicity, risk estimation in work activities involving exposure to NM.
- Identification of exposure and effect biomarkers (inflammation, oxidative stress, fibrogenesis, increased epithelial permeability) and their epidemiological validation in occupational contexts in which nanomaterials are produced or used.
- Characterization of micro-and nano-plastics; studies about occupational exposure to MNPL through combined environmental and biological monitoring strategies; study of specific biomarkers effects on the respiratory system and on the gastro-intestinal system.
Occupational and environmental determinants of chronic inflammatory bowel diseases (IBD):
- Case-control study addressed to establish the role of particulates and metal oxides used as food additives or in some work processes in the genesis of IBD. The research unit deals in particular with the development of analytical methods for the processing, the quantitative analysis and the ultramicroscopic characterization and in microanalysis (SEM-EDX) of exogenous materials in biopsy tissues taken from patients with suspected / ascertained diagnosis. by IBD.